|
Symbol Name ID |
Il4
interleukin 4 MGI:96556 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Recurrent pharyngitis |
Allergic rhinitis |
Conjunctivitis |
Pericarditis |
Lymphadenopathy |
Mediastinal lymphadenopathy |
Hepatosplenomegaly |
Peritoneal abscess |
Iridocyclitis |
Epididymitis |
Eczematoid dermatitis |
Atopic dermatitis |
Erythema nodosum |
Recurrent skin infections |
Platelet antibody positive |
Asthma |
Meningitis |
| Disease(s) Associated with IL4 | |||||||||||||||||
| asthma | |||||||||||||||||
| atopic dermatitis | |||||||||||||||||
| autoimmune thrombocytopenic purpura | |||||||||||||||||
| Behcet's disease | |||||||||||||||||
| pancreatic cancer | |||||||||||||||||
| temporal arteritis |
| Mouse Phenotypes | immune system phenotype |
abnormal dendritic cell differentiation |
increased mast cell degranulation |
ileum inflammation |
salivary gland inflammation |
stomach inflammation |
abnormal thymus morphology |
abnormal thymus cell ratio |
thymus cortex hypoplasia |
thymus hypoplasia |
abnormal thymocyte activation |
lacrimal gland inflammation |
insulitis |
abnormal T cell differentiation |
abnormal T-helper 2 cell differentiation |
increased double-negative T cell number |
decreased double-positive T cell number |
decreased basophil cell number |
decreased eosinophil cell number |
increased eosinophil cell number |
abnormal T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
absent CD8-positive, alpha-beta T cells |
increased CD8-positive, alpha-beta T cell number |
abnormal microglial cell morphology |
impaired eosinophil recruitment |
abnormal mast cell physiology |
increased IgA level |
decreased IgE level |
increased IgE level |
decreased IgG1 level |
increased IgG1 level |
decreased IgG2a level |
increased IgG2a level |
increased IgG2c level |
decreased IgG level |
increased IgG level |
decreased IgM level |
abnormal T-helper 2 physiology |
abnormal T cell activation |
abnormal osteoclast physiology |
abnormal splenocyte physiology |
abnormal immune system physiology |
abnormal dendritic cell antigen presentation |
abnormal humoral immune response |
abnormal cytokine secretion |
decreased interferon-gamma secretion |
increased interferon-gamma secretion |
decreased interleukin-10 secretion |
decreased interleukin-13 secretion |
increased interleukin-13 secretion |
decreased interleukin-3 secretion |
abnormal interleukin-4 secretion |
decreased interleukin-4 secretion |
increased interleukin-4 secretion |
decreased interleukin-5 secretion |
increased interleukin-5 secretion |
autoimmune response |
decreased susceptibility to autoimmune disorder |
increased susceptibility to autoimmune disorder |
granulomatous inflammation |
decreased inflammatory response |
CNS inflammation |
blepharitis |
conjunctivitis |
skin inflammation |
dermatitis |
abnormal response to infection |
abnormal susceptibility to infection |
increased susceptibility to bacterial infection |
increased susceptibility to parasitic infection induced morbidity/mortality |
decreased susceptibility to parasitic infection |
increased susceptibility to parasitic infection |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4/Il13tm3Anjm/Il4/Il13tm3Anjm | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm1.1Wep/Il4tm1.1Wep | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm1Cgn/Il4tm1Cgn | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm1Kopf/Il4tm1Kopf | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm1Nnt/Il4tm1Nnt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm1Rao/Il4tm1Rao | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm2.1Kubo/Il4tm2.1Kubo | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm2Nnt/Il4tm2Nnt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm3.1Kubo/Il4tm3.1Kubo | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il4tm1.1Wep/Il4+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(KRT14-Il4)#Lsch/0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(LckIl4)1315Dbl/0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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